Forskolin helps to lose weight and decreases the asthmatic problem therapeutically. But the majority of the users use Forskolin as a nootropic (to enhance memory or other cognitive functions) supplement. It has been derived from the leaves mint plant; Forskolin works with brain enzymes to promote health and productivity in neural tissue.
How does Forskolin work therapeutically?
Forskolin works by stimulating adenylate cyclase, a key enzyme in the brain which is a part of the ATP (Adenosine triphosphate) responsible for burning cellular energy and metabolism and Forskolin converts adenylate cyclase into cAMP (Cyclic adenosine monophosphate). cAMP involves in the cognitive mechanism by which the brain physically converts short term memories into long. This process is called a long-term Potentiation. LTP creates intact between individual neurons, allows signaling between the neurons. Once we start aging, neurons and synapses generally lose their ability to grow and communicate freely. This causes memory impairment and loss of motor control such as seen in Alzheimer’s and Parkinson’s disease patients.
Forskolin works as a conventional asthma drug by increasing cAMP levels which helps to relax bronchial muscles and eases breathing. It has also been used to treat glaucoma and it may help to relieve the pressure on eyes that is often experienced in glaucoma. But that was tested only with normal people and not with glaucoma patients. This drug is used to treat in the IV form to improve the heart function. The quality of active ingredients and concentration levels in the products vary from every manufacturer. However, it is advised to take Forskolin after seeking an advice from a health profession.
Forskolin Bodybuilding Benefits
Forskolin increases the fat loss by boosting the testosterone level in male and greatly suppresses the appetite. Adenylate cyclase an enzyme is activated which triggers the lipase activation, a digestive enzyme responsible for breaking down fat for fueling. Adenylate cyclase also plays an important role in the production of testosterone, giving Forskolin multiple fat fighting characteristics. Women are equally participating in bodybuilding nowadays. Direct application of Forskolin on the skin leads to spot fat reduction; however, further studies are needed to come to a substantial conclusion.
A small research was made between overweight and obese men and allowed them to take 250 mg of a 10% Forskolin extract twice a day. After twelve weeks, the persons lost huge fat and increased with testosterone levels. However, more research is needed to confirm the results. Along with benefits of Forskolin, the negative impacts must be considered as well.
What are the negative effects of Forskolin?
- When Forskolin is used through intravenous flushing and low blood pressure was noticed
- When inhaling causes upper respiratory tract irritation, tremor, anxiety, and cough
- While using as eye drops it makes stinging sensation in the eyes as well as enlarges the eye blood vessels
- Increases heart rate and headache
Forskolin should not be taken by the patients who take blood thinners and anti-platelet drugs. Certain high blood pressure drugs interact with Forskolin are Calcium channel blockers, Hydralazine, Beta-blockers. Forskolin should be avoided during pregnancy and breastfeeding and the patients who have polycystic kidney ailment. Before going for Forskolin the side effects must be considered as well.